Association of Decrease in Body Mass Index With Reduced Incidence and Progression of the Structural Defects of Knee Osteoarthritis: A Prospective Multi‐Cohort Study
Authors' conclusion
A decrease in BMI was independently associated with lower odds of incidence and progression of the structural defects of knee osteoarthritis
Study context
- Population
- Knees from 3 independent cohort studies (Osteoarthritis Initiative (OAI), Multicenter Osteoarthritis Study (MOST), CHECK) with radiographs at baseline and 4–5 years of follow-up
- Exposure
- Change in body mass index (BMI) from baseline to 4-5 years of follow-up
- Outcome
- Incidence and progression of radiographic structural defects of knee OA
- Follow-up
- 4-5 years
Methodological detailsmulti-cohort (OAI, MOST, CHECK), logistic regression with generalized estimating equations, clustering of both knees within individuals
- Multi-cohort (OAI, MOST, CHECK)
- Logistic regression with generalized estimating equations
- Clustering of both knees within individuals
Main finding
As reported in the abstract
Adjusted OR for OA incidence (incidence cohort: 9,683 knees, 5,774 participants), 95% CI 1.02-1.09
1.05
Adjusted OR for OA progression (progression cohort: 6,075 knees, 3,988 participants), 95% CI 1.01-1.09
1.05
Observational data: associations, not effects.
Further findings
Joint space narrowing and osteophytes (femoral and tibial surfaces)
- Change in BMI positively associated on the medial but not on the lateral side of the knee
Original publication
Association of Decrease in Body Mass Index With Reduced Incidence and Progression of the Structural Defects of Knee Osteoarthritis: A Prospective Multi‐Cohort Study. Arthritis Rheumatol. Published 30 January 2023. doi:10.
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