Association Between Change in Body Mass Index and Knee and Hip Replacements: A Survival Analysis of Seven to Ten Years Using Multicohort Data
Study context
- Population
- Adults (45–79 years of age) with or at risk of clinically significant knee OA, from Osteoarthritis Initiative (OAI), Multicenter Osteoarthritis Study (MOST) and CHECK8,181 (knees)
- Exposure
- Change in body mass index (BMI) as exposure, for risk of knee and hip replacement
- Outcome
- Incidence of primary knee and hip replacement
- Follow-up
- 7-10 years'
Methodological detailspooled analysis of 3 cohorts, multicohort (OAI, MOST, CHECK), Cox proportional hazards regression, clustering of both knees and hips per person
- Pooled analysis of 3 cohorts
- Multicohort (OAI, MOST, CHECK)
- Cox proportional hazards regression
- Clustering of both knees and hips per person
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)
Change in BMI: knee replacement16,362 knees
1.03(1.00–1.06)
Change in BMI: hip replacement16,406 hips
1.00(0.95–1.04)
Observational data: associations, not effects.
Further findings
Knee replacement by baseline BMI category (normal, overweight, obese)
- Association between change in BMI and knee replacement independent of baseline BMI category
Original publication
Association Between Change in Body Mass Index and Knee and Hip Replacements: A Survival Analysis of Seven to Ten Years Using Multicohort Data. Arthritis Care Res (Hoboken). Published 5 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →