Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study
Authors' conclusion
Individuals with obesity and concurrent low muscle or cardiometabolic comorbidities have persistent worse functioning over a seven-year period compared to those with obesity alone.
Study context
- Population
- Multicenter Osteoarthritis Study (MOST) participants with or at risk for knee osteoarthritis (OA), body mass index (BMI) ≥30 kg/m² and DXA-measured body composition (63% female, mean age 61.2 ± SD 7.6 years, mean BMI 35.0 ± SD 4.5 kg/m²)
- Participants
- 1,211 participants
- Exposure
- Obesity with low muscle mass and obesity with cardiometabolic comorbidities vs uncomplicated obesity
- Outcome
- Longitudinal trajectories of self-reported WOMAC physical function
- Follow-up
- 7 years
Methodological detailsmulticentre, linear regression, multinomial logistic regression
- Multicentre
- Linear regression
- Multinomial logistic regression
Main finding
As reported in the abstract
Persistent poorest functioning trajectory
Odds ratio
1.9
OLM
Odds ratio
2.6
Obesity with cardiometabolic comorbidities (OCC)
Observational data: associations, not effects.
Further findings
Physical function at baseline
- OLM and OCC had worse physical function than uncomplicated obesity (UO)
Original publication
Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study. Arthritis Care Res (Hoboken). Published 12 May 2026. doi:10.
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