A cross-sectional study of associations between constitutional morphological features and individual radiographic phenotypes of hip osteoarthritis
Authors' conclusion
Person-specific pre-OA morphological features associate with different phenotypes of hip OA based on the site of minimum JSW.
Study context
- Population
- Symptomatic unilateral hip osteoarthritis (OA) cases referred for joint replacement (Genetics of Osteoarthritis and Lifestyle (GOAL) database)
- Participants
- 566 cases
- Exposure
- Tertiles of constitutional morphological features (unaffected contralateral hip) vs radiographic OA phenotypes by site of minimum joint space width (JSW)
- Outcome
- Radiographic hip OA phenotype classified by site of minimum JSW
Methodological detailsGOAL database, logistic regression adjusted for confounding factors, tertiles for dose response, Unaffected hips assumed to reflect pre-OA constitutional morphology of the contralateral affected hip
- GOAL database
- Logistic regression adjusted for confounding factors
- Tertiles for dose response
- Unaffected hips assumed to reflect pre-OA constitutional morphology of the contralateral affected hip
Main finding
As reported in the abstract
Associations of morphological features (highest tertile) with hip OA phenotypes
Odds ratio (95% CI)
MCD (higher)superolateral pattern
5.17(2.18–12.23)
MCD (higher)superior intermediate pattern
5.05(1.98–12.90)
SAsuperolateral pattern
3.27(1.47–7.26)
SAsuperior intermediate pattern
2.39(1.01–5.68)
NSAsuperolateral pattern
2.14(1.01–4.71)
FHNRsuperomedial pattern
4.22(1.49–11.89)
Observational data: associations, not effects.
Original publication
A cross-sectional study of associations between constitutional morphological features and individual radiographic phenotypes of hip osteoarthritis. Osteoarthritis Cartilage. Published 11 May 2026. doi:10.
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