Association of quantitative measures of medial meniscal extrusion with structural and symptomatic knee osteoarthritis progression – Data from the OAI FNIH biomarker study
Main findingResult — go to the resultOdds ratio 1.59 95% CI 1.25,2.04Authors' conclusion
Baseline measures of medial meniscal extrusion were consistently positively associated with combined radiographic/symptomatic progression and with isolated structural, but not with isolated symptomatic progression.
Study context
- Population
- Knees of FNIH OAI Biomarkers study participants; radiographic and symptomatic knee osteoarthritis (OA) progression over 2–4 years4 subgroups
- Participants
- 600 participants
- Comparison
- Combined structural/symptomatic progressor knees vs knees with neither structural nor symptomatic progression
- Combined progressionn = 194
- Non-progressionn = 200reference
- Isolated structuraln = 103
- Isolated symptomaticn = 103
- Outcome
- Association of quantitative medial meniscal position measures (coronal DESS MRI) with combined structural/symptomatic knee OA progression
- Follow-up
- 2-4 years
Methodological detailslogistic regression adjusted for demographic and clinical data
- Logistic regression adjusted for demographic and clinical data
Main finding
As reported in the abstract
baseline
Odds ratio
1.59
95% CI 1.25,2.04
Combined progressionvs Non-progression
OR 1.59 (95% CI 1.25,2.04)
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | |
|---|---|---|
| Two-year change in meniscal position measures and combined progression · 2 yearsCombined progressionvs Non-progressionIncrease in meniscal extrusion | 1.48 (1.21–1.83) | |
| Two-year change in meniscal position measures and combined progression · 2 yearsCombined progressionvs Non-progressionReduction in tibial plateau coverage | 0.70 (0.58,0.86) | |
| Two-year change in meniscal position measures and combined progression · 2 yearsCombined progressionvs Non-progressionReduction in overlap distance | 0.73 (0.60,0.89) | |
| 0.512Odds ratio (log scale) |
Baseline extrusion and isolated progression
- Greater baseline extrusion associated with isolated structural progression
- Less extrusion associated with isolated symptomatic progression
Longitudinal change in meniscal position and isolated progression
- Longitudinal increase in extrusion and reduction in tibial plateau coverage and overlap distance associated with structural, but not with symptomatic progression
Original publication
Association of quantitative measures of medial meniscal extrusion with structural and symptomatic knee osteoarthritis progression – Data from the OAI FNIH biomarker study. Osteoarthritis Cartilage. Published 25 July 2023. doi:10.
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