MRI versus radiography as eligibility screening tool for knee osteoarthritis clinical trials: Data from the osteoarthritis initiative
Authors' conclusion
Structural pathologies that are unlikely to respond to investigational DMOADs were found in ∼10 % of eligible participants based on MRI screening, largely driven by complete meniscal root tears, while these findings were not visible on radiographs.
Study context
- Population
- Osteoarthritis Initiative baseline participants meeting disease-modifying osteoarthritis drug (DMOAD) trial eligibility: KL grade 2 or 3 with medial minimum joint space width ≥ 1.5 mm and WOMAC knee pain 8–18 (0–20 scale)219 KL2 knees · 161 KL3 knees
- Participants
- 380 participants
- Exposure
- MRI vs radiography for detection of exclusionary knee structural pathologies
- Outcome
- Prevalence of knee structural pathologies warranting exclusion from DMOAD trials (ROAMES), MRI vs radiography
Methodological detailsdata from the Osteoarthritis Initiative, baseline visit, single musculoskeletal radiologist read
- Data from the Osteoarthritis Initiative
- Baseline visit
- Single musculoskeletal radiologist read
Main finding
As reported in the abstract
Knees with exclusionary structural pathologies
Observational data: associations, not effects.
Further findings
Estimated probability of exclusionary finding on MRI, by KL grade
- KL2 knee
- 0.06 (95 %CI: 0.03, 0.09)
- KL3 knee
- 0.16 (95 %CI: 0.10, 0.21)
Complete meniscus posterior root tear (most common finding)
- Knees
- 31 knees, 8.2 %
Original publication
MRI versus radiography as eligibility screening tool for knee osteoarthritis clinical trials: Data from the osteoarthritis initiative. Semin Arthritis Rheum. Published 28 August 2025. doi:10.
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