Alcohol Consumption and Risk of Total Hip Replacement Due to Hip Osteoarthritis in Women
Authors' conclusion
Higher alcohol consumption was associated with greater incidence of total hip replacement due to hip osteoarthritis in a dose-dependent manner in women.
Study context
- Population
- Women in the Nurses' Health Study cohort (US) without diagnosed OA in 1988, followed to June 20121,796 cases
- Participants
- 83,383 women
- Exposure
- Alcohol consumption categories vs nondrinkers
- Outcome
- Total hip replacement due to hip OA (self-reported OA with hip replacement)
Methodological detailsmultivariable hazard ratios (HRs), cumulative averages and simple updates with latency periods of 0-4 through 20-24 years, Alcohol consumption assessed every 4 years, starting in 1980
- Multivariable HRs
- Cumulative averages and simple updates with latency periods of 0-4 through 20-24 years
- Alcohol consumption assessed every 4 years, starting in 1980
Main finding
As reported in the abstract
Total hip replacement due to hip OA
Each group vs nondrinkersMultivariable hazard ratio (95% CI)P value
>0 to <5 g/day
1.04(0.90–1.19)
5 to <10 g/day
1.12(0.94–1.33)
10 to <20 g/day
1.31(1.10–1.56)
≥20 g/day
1.34(1.09–1.64)
P < 0.0001for trendObservational data: associations, not effects.
Further findings
Latency analyses and consumption at age 35-40 years
- Association held in latency analyses of up to 16-20 years, and for alcohol consumption between 35-40 years of age
Individual alcohol types (wine, liquor, beer), HR per 10 g alcohol
- Multivariable HRs similar for wine, liquor and beer; P = 0.57 for heterogeneity among alcohol types
- Independent of other alcoholic beverages
Original publication
Alcohol Consumption and Risk of Total Hip Replacement Due to Hip Osteoarthritis in Women. Arthritis Rheumatol. Published 20 July 2023. doi:10.
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