Association between baseline meniscal extrusion and long-term incident knee osteoarthritis in two different cohorts
Main finding · Incident radiographic knee OA, PROOFResult — go to the resultAdjusted odds ratio 2.54 95% CI 1.34–4.80Authors' conclusion
Meniscal extrusion is significantly associated with long-term incident KOA. A high number of incident cases were attributable to extrusion.
Study context
- Population
- PROOF: high-risk population of overweight women; Rotterdam Study (RS): female subcohort of the population-based Rotterdam Study421 knees (PROOF)
- Exposure
- Knees with vs without baseline meniscal extrusion
- Outcome
- Incident radiographic (KL ≥ 2) or clinical knee OA according to the ACR criteria
- Follow-up
- 6.6 years (PROOF) and 5.1 years (RS)
Methodological detailstwo cohorts (PROOF and Rotterdam Study female subcohort), generalized estimating equations, adjusted for confounders
- Two cohorts (PROOF and Rotterdam Study female subcohort)
- Generalized estimating equations
- Adjusted for confounders
Main finding
Incident radiographic knee OA, PROOF · 6.6 years
Adjusted odds ratio
2.54
95% CI 1.34–4.80
P = 0.004
Meniscal extrusionvs No meniscal extrusion
aOR 2.54 (95% CI 1.34–4.80); P = 0.004
As reported in the abstract
- Knees with baseline meniscal extrusion (PROOF)
- 23%
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between baseline meniscal extrusion and long-term incident knee osteoarthritis in two different cohorts. Semin Arthritis Rheum. Published 29 January 2023. doi:10.
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