Improvement of rhizarthrosis pain management with the infiltration of hyaluronic acid and corticosteroids versus corticosteroids alone
Primary result · Reduction of pain during activity (VAS 0-10)Result — go to the resultDifference −1.1 points on a 0-10 VAS 95% CI −1.9 to −0.2Authors' conclusion
In patients with painful rhizarthrosis, the infiltrations of hyaluronic acid and corticosteroids demonstrate better efficacy in reducing pain during activity 3months after intervention, compared to injections with only corticosteroids.
Study context
- Population
- Patients with painful rhizarthrosis (trapeziometacarpal OA)149 received injection
- Participants
- 150 patients
- Comparison
- Hyaluronic acid plus corticosteroid infiltration vs saline plus corticosteroid infiltration
- Hyaluronic acid+corticosteroidn = 74
- Corticosteroids+placebon = 76reference
- Primary endpoint
- Reduction of pain during activity (VAS 0-10)
- Follow-up
- M3
Methodological detailssingle-blind, two parallel groups, blinded evaluation
- Single-blind
- Two parallel groups
- Blinded evaluation
Primary result
As reported in the abstract
Difference
−1.1 points on a 0-10 VAS
95% CI −1.9 to −0.2
P = 0.012
Hyaluronic acid+corticosteroidvs Corticosteroids+placebo
difference −1.1 points on a 0-10 VAS (95% CI −1.9 to −0.2); P = 0.012
Secondary outcomes
VAS scores at rest and during activity at M1, M6 and M12
- Improvements observed, although not statistically significant (except at M1)
Grip and opposition strength
- Remained unchanged between groups along the follow-up
Original publication
Improvement of rhizarthrosis pain management with the infiltration of hyaluronic acid and corticosteroids versus corticosteroids alone. Joint Bone Spine. Published 30 January 2025. doi:10.
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