Identification of biomarkers associated with pyroptosis and autophagy in facet joint osteoarthritis
Authors' conclusion
Our study identified CD274, DDX3X, Caspase-8, and MAPK14 in chondrocyte and articular cartilage of articular process with pyroptosis and autophagy in FJOA.
Study context
- Population
- Lumbar facet joints from patients with facet joint OA (facet joint osteoarthritis (FJOA))
- Outcome
- DEGs linked to pyroptosis and autophagy in FJOA and potential biomarkers for FJOA
Methodological detailstranscriptome sequencing, bioinformatics, machine learning, clinical sample and cellular validation
- Transcriptome sequencing
- Bioinformatics
- Machine learning
- Clinical sample and cellular validation
Main finding
As reported in the abstract
Differentially expressed genes (DEGs) in FJOA samples
7,783
Autophagy-related genes from GeneCards
1,153
Pyroptosis-related genes from GeneCards
80
And pyroplosis-related genes (APRGs) from the intersection of the three gene sets
17
Original publication
Identification of biomarkers associated with pyroptosis and autophagy in facet joint osteoarthritis. Clin Exp Rheumatol. Published 29 January 2025. doi:10.
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