The responsiveness of digital biomarkers as measurement tools in people with hip and knee osteoarthritis: A systematic review and meta-analysis
Authors' conclusion
Digital biomarkers related to mobility measures, have the potential for greater uptake in OA clinical trials to assess mobility health in community and home-settings.
Study context
- Population
- People living with hip and/or knee osteoarthritis (OA) in community or home settings; mean age 64 (SD=4) years, most with knee OA40 studies · 18 digital biomarkers
- Comparison
- Cadence vs Walking speed vs Step count vs Energy expenditure
- Outcome
- Responsiveness of digital biomarkers (standardized response means (SRMs))
Methodological detailsrandom-effects model, subgroup analyses (intervention vs non-intervention; short, medium, long-term), Accelerometers (95%) most commonly used technology type, Overall quality of studies high
- Random-effects model
- Subgroup analyses (intervention vs non-intervention; short, medium, long-term)
- Accelerometers (95%) most commonly used technology type
- Overall quality of studies high
Pooled result
As reported in the abstract
Responsiveness (SRM)
Cadence
0.65
SRM · 95% CI 0.42–0.87
Walking speed
0.43
SRM · 95% CI 0.15–0.70
Step count
0.19
SRM · 95% CI 0.02–0.36
Energy expenditure
−0.16
SRM · 95% CI −0.31–-0.01
Original publication
The responsiveness of digital biomarkers as measurement tools in people with hip and knee osteoarthritis: A systematic review and meta-analysis. Osteoarthritis Cartilage. Published 17 February 2026. doi:10.
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