Per‐ and Polyfluoroalkyl Substances and Hand Osteoarthritis: Data From the Osteoarthritis Initiative
Authors' conclusion
We observed possible associations of PFDA and PFNA serum concentrations with symptomatic HOA incidence, but we otherwise found no consistent evidence that greater PFAS concentrations relate to a greater chance of developing HOA incidence or progression.
Study context
- Population
- Case-cohort sample from the Osteoarthritis Initiative; primarily female (58%), mean age 62 years, mean BMI 28.6 kg/m²
- Participants
- 1,878 participants
- Exposure
- Higher vs lower serum levels of eight PFAS
- Outcome
- Incident symptomatic hand OA, OR per IQR increment
- Follow-up
- 4 years
Methodological detailsweighted logistic regression, quantile g-computation for PFAS mixture
- Weighted logistic regression
- Quantile g-computation for PFAS mixture
Main finding
As reported in the abstract
Odds ratio (95% CI)
PFDA (per IQR increment)
1.12(1.05–1.20)
PFNA (per IQR increment)
1.07(1.00–1.13)
Perfluorohexane sulfonic acid (per IQR increment)incident HOA; given as example (eg)
0.94(0.88–1.00)
Per IQR increment, as printed
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Per‐ and Polyfluoroalkyl Substances and Hand Osteoarthritis: Data From the Osteoarthritis Initiative. Arthritis Rheumatol. Published 17 February 2026. doi:10.
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