Association of Weight Loss and Weight Gain With Structural Defects and Pain in Hand Osteoarthritis: Data From the Osteoarthritis Initiative
Authors' conclusion
Our study found no evidence of an association between weight change and the odds of incidence or progression of radiographic hand OA over 4 years, nor the development or resolution of hand pain over 8 years.
Study context
- Population
- Osteoarthritis Initiative participants, excluding those with cancer, RA or BMI under 18.5 kg/m²selected from 4,796
- Participants
- 4,598 participants
- Exposure
- Weight change, per 5% weight loss
- Outcome
- Incidence and progression of radiographic hand OA; development and resolution of hand pain
- Follow-up
- 4-year (radiographic); up to 8-year (pain)
Methodological detailsOsteoarthritis Initiative data, multivariable logistic regression, repeated-measure mixed-effects logistic regression
- Osteoarthritis Initiative data
- Multivariable logistic regression
- Repeated-measure mixed-effects logistic regression
Main finding
As reported in the abstract
Radiographic hand OA, per 5% weight loss · 4-year follow-up
Incidence of radiographic hand osteoarthritis (OA), OR
0.90
95% CI 0.67–1.23
Progression of radiographic hand OA, OR
0.92
95% CI 0.84–1.00
Observational data: associations, not effects.
Further findings
Hand pain, per 5% weight loss · 8-year follow-up
- Development of hand pain, OR
- 1.00 (95% CI 0.92-1.09)
- Resolution of hand pain, OR
- 1.07 (95% CI 0.91-1.25)
Original publication
Association of Weight Loss and Weight Gain With Structural Defects and Pain in Hand Osteoarthritis: Data From the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). Published 5 February 2024. doi:10.
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