Effects of Weight Change on Knee and Hip Radiographic Measurements and Pain Over Four Years: Data From the Osteoarthritis Initiative
Authors' conclusion
This large, longitudinal study (n = 2,752 with 4-year follow-up) suggests that weight loss may protect against, and weight gain may exacerbate, radiographic and symptomatic knee OA, while weight change (at a 5% threshold) does not have significant effects on hip OA.
Study context
- Population
- Participants from the Osteoarthritis Initiative
- Participants
- 2,752 participants
- Exposure
- Weight gain or weight loss vs controls over 4 years
- Outcome
- 4-year changes in knee radiographic osteoarthritis (OA) (K/L grade), hip OA (Croft summary grade), joint space narrowing (JSN) and joint pain
- Follow-up
- 4 years
Methodological detailsgeneralized estimating equations adjusted for age, sex and BMI
- Generalized estimating equations adjusted for age, sex and BMI
Main finding
As reported in the abstract
Each group vs controlsOdds ratio (95% CI)P value
Weight lossK/L grade worsening (radiographic knee OA)
0.69(0.53–0.91)
P = 0.009Weight gainmedial knee JSN
1.29(1.01–1.64)
P = 0.038Weight lossknee pain resolution
1.40(1.06–1.86)
P = 0.019Weight gainknee pain development
1.34(1.08–1.67)
P = 0.009- All hip outcomes: no significant associations with weight-change groups
- P > 0.05
Observational data: associations, not effects.
Further findings
Total hip or total knee replacement
- Associations with weight-change group not significant
- P > 0.05
Original publication
Effects of Weight Change on Knee and Hip Radiographic Measurements and Pain Over Four Years: Data From the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). Published 18 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →