Thigh muscle composition changes in knee osteoarthritis patients during weight loss: Sex-specific analysis using data from osteoarthritis initiative
Main finding · Change in Intra-MAT, mm²/4-yearResult — go to the resultChange difference 783.44 mm²/4-year 95% CI 505.70–1061.19Authors' conclusion
In participants with KOA and 4-year weight loss, the longitudinal changes in thigh muscle quality were overall beneficial but to a less degree in females compared to males.
Study context
- Population
- Osteoarthritis Initiative (OAI) participants with baseline radiographic knee OA and >5% reduction in Body Mass Index (BMI) over four years
- Participants
- 313 thighs
- Exposure
- Females vs males with knee OA and >5% BMI reduction over four years
- Femalesn = 192
- Malesn = 121reference
- Outcome
- Change in Intra-MAT, Inter-MAT and contractile percentage of thigh muscles (MRI-derived), females vs males
- Follow-up
- 4 years
Methodological detailslongitudinal, secondary analysis of Osteoarthritis Initiative (OAI) cohort data, deep-learning Magnetic Resonance Imaging (MRI) analysis, adjusted for potential confounders
- Longitudinal
- Secondary analysis of Osteoarthritis Initiative (OAI) cohort data
- Deep-learning MRI analysis
- Adjusted for potential confounders
Main finding
Change in Intra-MAT, mm²/4-year
Change difference
783.44 mm²/4-year
95% CI 505.70–1061.19
P < 0.001
Femalesvs Males
change difference 783.44 mm²/4-year (95% CI 505.70–1061.19); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Change difference (%/4-year) (95% CI) | P value | |
|---|---|---|---|
| Change in contractile percentage of thigh muscles · 4 yearsLess increase in females | −3.9 (−6.5 to −1.4) | P = 0.019 | |
| −10−505Difference, %/4-year (linear scale) |
| Outcome | Females | Males | P value |
|---|---|---|---|
| Weight loss (BMI change) · 4 yearsComparable degree of weight loss | −9.72 ± 4.38 | −8.83 ± 3.64 | P = 0.060 |
Original publication
Thigh muscle composition changes in knee osteoarthritis patients during weight loss: Sex-specific analysis using data from osteoarthritis initiative. Osteoarthritis Cartilage. Published 6 June 2024. doi:10.
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