Association Between Metabolically Different Adiposity Subtypes and Osteoarthritis: A Mendelian Randomization Study
Authors' conclusion
Metabolic abnormalities did not explain the association between greater adiposity and the risk of osteoarthritis, which might suggest that the association is largely due to a mechanical effect on the joints.
Study context
- Population
- Summary-level GWAS data for OA from UK Biobank and site-specific OA from the Arthritis Research UK Osteoarthritis Genetics consortium10,083 cases and 40,425 controls
- Comparison
- Genetically predicted metabolically unfavorable, neutral and favorable adiposity (all increasing BMI) and OA
- Outcome
- OA (IVW primary analysis)
Methodological details2-sample Mendelian randomization (MR), inverse variance weight (IVW) primary analysis, sensitivity analyses with different MR methods, nonlinear MR
- 2-sample MR
- IVW primary analysis
- Sensitivity analyses with different MR methods
- Nonlinear MR
Main finding
As reported in the abstract
OA
Estimate (95% CI)
Metabolically unfavorable adiposity
IVW OR 1.56(1.31–1.85)
Metabolically neutral adiposity
OR 1.60(1.15–2.23)
Metabolically favorable adipositysimilar, although with notable imprecision
OR 1.55(0.70–3.41)
Further findings
Knee OA (site-specific)
| OR (95% CI) | ||
|---|---|---|
| Metabolically unfavorable adiposity | 1.44 (1.04–1.98) | |
| Metabolically neutral adiposity | 2.28 (1.04–4.99) | |
| Metabolically favorable adiposity | 6.80 (2.08–22.19) | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | P value |
|---|---|
| Nonlinear MR: metabolically unfavorable adiposity and OA | Pnonlinear = 0.003 |
Other MR methods (sensitivity)
- Generally consistent estimates with a wider CI crossing the null
Original publication
Association Between Metabolically Different Adiposity Subtypes and Osteoarthritis: A Mendelian Randomization Study. Arthritis Care Res (Hoboken). Published 17 November 2022. doi:10.
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