Osteoporosis and osteoarthritis: a bi-directional Mendelian randomization study
Authors' conclusion
These findings suggested that OP may be causally linked to an increased risk of OA
Study context
- Population
- Summary-level data on osteoarthritis (OA) traits from UK Biobank and arcOGEN
- Comparison
- Genetically predicted low bone mineral density (BMD) vs OA traits, and reverse
- Outcome
- Causal relationship between low BMD and OA
Methodological detailsInverse variance weighting (IVW) with sensitivity analyses (MR-Egger, simple median, weighted median, MR-PRESSO), gene ontology (GO) enrichment and expression quantitative trait locus (eQTL) colocalization analyses
- IVW with sensitivity analyses (MR-Egger, simple median, weighted median, MR-PRESSO)
- GO enrichment and eQTL colocalization analyses
Main finding
As reported in the abstract
Genetically predicted low BMD and OA (IVW)
- Low femoral neck BMD – hip OA, β
- 0.105 (0.023-0.188) (95% CI)
- Low femoral neck BMD – knee OA, β
- 0.117 (0.049-0.184) (95% CI)
- Low femoral neck BMD – other site-specific OA
- not significant
- Low lumbar spine BMD – OA at any site, β
- 0.048 (0.011-0.085) (95% CI)
- Low lumbar spine BMD – knee OA, β
- 0.101 (0.045-0.156) (95% CI)
- Low lumbar spine BMD – hip OA, β
- 0.150 (0.077-0.224) (95% CI)
- Reduced total bone BMD – hip OA (only significant site), β
- 0.092 (0.010-0.174) (95% CI)
Further findings
Reverse Mendelian randomization (MR): OA on BMD
- No evidence for a causal effect of OA on BMD
GO enrichment and eQTL analysis
- DDN and SMAD-3 the most prominent co-located genes
Original publication
Osteoporosis and osteoarthritis: a bi-directional Mendelian randomization study. Arthritis Res Ther. Published 13 December 2023. doi:10.
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