Evaluation of a measure of end-stage knee osteoarthritis compared to total knee replacement: An observational study using multicohort data
Authors' conclusion
The esKOA measure enables shorter and smaller studies compared to using TKR as an outcome.
Study context
- Population
- Participants of the Osteoarthritis Initiative (OAI) and the Multicenter Osteoarthritis Study (MOST)10,357 knees
- Participants
- 5,593 participants
- Exposure
- End-stage knee osteoarthritis (esKOA) measure vs total knee replacement (TKR) as outcome for detecting association of weight loss
- Outcome
- Association between weight loss and odds of esKOA and TKR; required sample sizes to detect a 10, 20, or 50% reduction in incidence
- Follow-up
- 2-to-2.5-year and 4-to-5-year follow-ups
Methodological detailsmulticohort (OAI and MOST)
- Multicohort (OAI and MOST)
Main finding
As reported in the abstract
Association of weight loss with esKOA and TKR; required sample sizes
Required sample sizes for esKOA smaller than for TKR at the 4-to-5-year and 2-to-2.5-year follow-ups, respectively
85% to 93%
Observational data: associations, not effects.
Original publication
Evaluation of a measure of end-stage knee osteoarthritis compared to total knee replacement: An observational study using multicohort data. Semin Arthritis Rheum. Published 10 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →