Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization
Authors' conclusion
Joint immobilization caused multiple OA-like lesions in both mice and humans. Joint immobilization induced progressive sensory innervation, synovitis, osteophyte formation, and cartilage loss in mice, which can be partially ameliorated by remobilization.
Study context
- Population
- Patients after an extraarticular fracture or ligament injury with long-term joint immobilization; mouse model of knee joint immobilization
- Comparison
- Joint immobilization and remobilization
Methodological detailsclinical observation in patients, mouse model of joint immobilization and remobilization
- Clinical observation in patients
- Mouse model of joint immobilization and remobilization
Main finding
As reported in the abstract
- Long-term (6 weeks) joint immobilization caused significant joint pain and osteophytes in patients
- In mice, 2-week immobilization induced moderate sensory innervation, increased pain sensitivity and synovial infiltration, without marked osteophyte formation or cartilage loss
- In mice, 4 and 8 weeks of immobilization induced more severe sensory innervation and synovial inflammatory infiltration, massive osteophyte formation (both sides of femoral condyle, edge of tibial plateau) and significant articular cartilage loss
- In mice, remobilization restored to a certain extent some osteoarthritis (OA) lesions and joint function
Original publication
Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization. Arthritis Res Ther. Published 7 December 2023. doi:10.
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