Cellular and molecular landscapes of inflammation in anterior cruciate ligament rupture patients are independent on concurrent meniscal injury
Authors' conclusion
The presence of concurrent meniscal injury did not influence cellular and molecular landscapes of inflammation and minimally affected patient reported outcome measures up to two years following anterior cruciate ligament reconstruction.
Study context
- Population
- Patients with an anterior cruciate ligament (ACL) rupture undergoing ACL reconstruction surgery
- Participants
- 24 patients
- Exposure
- ACL rupture with concurrent meniscal injury vs isolated ACL rupture with intact menisci
- Outcome
- Inflammatory cellular or molecular landscapes and patient reported outcome measures (PROMs) (knee function and pain)
Methodological detailssynovium, synovial fluid and blood collected at ACL reconstruction, flow cytometry, bulk RNA sequencing, luciferase reporter assays
- Synovium, synovial fluid and blood collected at ACL reconstruction
- Flow cytometry
- Bulk RNA sequencing
- Luciferase reporter assays
Main finding
As reported in the abstract
Synovial inflammation scores, cellular composition, synovial gene expression, pathway activation
- Heterogeneity in synovitis among patients, but no significant differences between isolated ACL rupture and concurrent meniscal injury in synovial inflammation scores, cellular composition, synovial gene expression, or pathway activation induced by serum or synovial fluid
Observational data: associations, not effects.
Further findings
PROM scores at ACL reconstruction · preoperatively
- Meniscal status did not affect PROM scores at time of ACL reconstruction
PROM scores (KOOS, EQ-5D) postoperatively · 6 months and 2 years postoperatively
- Generally better outcomes; concurrent meniscal injury showed subtly less improvement
Original publication
Cellular and molecular landscapes of inflammation in anterior cruciate ligament rupture patients are independent on concurrent meniscal injury. Arthritis Res Ther. Published 18 April 2026. doi:10.
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