Does mental health mediate the effect of nonsurgical exposures on pain and functional outcomes in osteoarthritis? A systematic review
Authors' conclusion
Our findings provide preliminary evidence that mental health may mediate the effect of nonsurgical exposures on functional outcomes in people with OA.
Study context
- Population
- People with osteoarthritis (OA); studies testing a mental health mediator between any non-surgical exposure and pain or functional outcomes32 models
- Participants
- 8,069 people11 studies
- Outcome
- Mental health mediators of nonsurgical exposures on pain and function
Methodological detailsCochrane Risk of Bias 2 and Joanna Briggs Institute critical appraisal tools, AGReMA reporting guideline, Searched PubMed, EMBASE, Scopus, PsycInfo, Web of Science, ClinicalTrials.gov and WHO ICTRP from inception through April 2025
- Cochrane Risk of Bias 2 and Joanna Briggs Institute critical appraisal tools
- AGReMA reporting guideline
- Searched PubMed, EMBASE, Scopus, PsycInfo, Web of Science, ClinicalTrials.gov and WHO ICTRP from inception through April 2025
Pooled result
As reported in the abstract
- Anxiety and mental health tested in two studies and mediated the relationships tested
- 2
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Does mental health mediate the effect of nonsurgical exposures on pain and functional outcomes in osteoarthritis? A systematic review. Osteoarthritis Cartilage. Published 16 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →