CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis
Authors' conclusion
Our results strongly support that targeting synovial and fat pad inflammation through blockade of CD14 can safely ameliorate OA pain and disability after a predisposing injury.
Study context
- Population
- Human osteoarthritis (OA) synovial fluid samples; mild to severe murine surgical and nonsurgical models of post-traumatic OA (PTOA), male and female cohorts, incl. obesity
- Comparison
- CD14 deficiency or intra-articular CD14 blocking antibody vs CD14-intact controls
Methodological detailshuman synovial fluid analysis, murine surgical and nonsurgical PTOA models, global genetic deletion of CD14, intra-articular CD14 blockade
- Human synovial fluid analysis
- Murine surgical and nonsurgical PTOA models
- Global genetic deletion of CD14
- Intra-articular CD14 blockade
Main finding
As reported in the abstract
- Increased soluble CD14 (sCD14) within human synovial fluid correlates with joint effusion volume and knee hyperalgesia
- Targeting CD14 protects against increased evoked pain behaviors and OA-driven mobility impairments across murine models differing in severity and in male and female cohorts
- CD14 deficiency modulates the synovial and fat pad inflammatory landscape post injury, reducing myeloid populations and modulating local fibroblast populations
- Local delivery of a CD14 blockade protects against OA-associated pain and mobility loss across surgical and nonsurgical PTOA models incorporating sex and obesity
Original publication
CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis. Arthritis Rheumatol. Published 24 February 2026. doi:10.
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