CRTAC1 as a biomarker for osteoarthritis: Link to inflammation and microRNA regulation
Authors' conclusion
CRTAC1 has emerged as a potential biomarker for OA, with SF levels associated to disease severity and inflammation.
Study context
- Population
- Individuals with knee osteoarthritis (OA) and controls; knee radiographs graded by Kellgren-Lawrence scale
- Participants
- 555 individuals
- Comparison
- OA vs controls
- OAn = 68
- PT-controlsn = 51reference
- Healthy controls (HC)n = 95reference
- Outcome
- CRTAC1 levels in SF and plasma, OA vs controls
Methodological detailsmass spectrometry with IQ-ELISA validation, miRNA sequencing with digital PCR validation
- Mass spectrometry with IQ-ELISA validation
- miRNA sequencing with digital PCR validation
Performance
As reported in the abstract
CRTAC1 levels, OA vs controls
CRTAC1 significantly higher in OA synovial fluid (SF) vs controls (fold)
33×
CRTAC1 significantly higher in OA plasma vs controls (fold)
32×
Further findings
CRTAC1 and OA severity
- CRTAC1 in SF correlated with OA severity (β)
- 0.5
- CRTAC1 in plasma not correlated with OA severity
CRTAC1 and eotaxin
- Association in SF (β)
- 0.14
- Association in plasma (β)
- 0.09
miRNAs downregulated in controls vs OA, inversely associated with CRTAC1 in SF
- miR-10a-5p (fold)
- 2.5×
- miR-107 (fold)
- 38×
- miR-186-5p (fold)
- 9.3×
Original publication
CRTAC1 as a biomarker for osteoarthritis: Link to inflammation and microRNA regulation. Osteoarthritis Cartilage. Published 22 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →