Do Not Throw Out the Radiographs! Radiographic Disease Severity as a Prognostic Biomarker for the Onset of Frequent Knee Pain
Authors' conclusion
Radiographic OA severity should be considered a potential prognostic biomarker to identify individuals at high risk of developing knee symptoms.
Study context
- Population
- Knees of Osteoarthritis Initiative participants without frequent knee symptoms at baseline3,407 participants
- Participants
- 5,653 participants
- Exposure
- Baseline Kellgren-Lawrence (KL) grades 1–4 vs KL 0
- Outcome
- Incident frequent knee symptoms (self-report)
- Follow-up
- 12 and 48 months
Methodological detailsknee-based logistic regression, generalized estimating equations
- Knee-based logistic regression
- Generalized estimating equations
Main finding
As reported in the abstract
Incident frequent knee symptoms · 12 months
Each group vs KL 0Odds ratio (95% CI)
KL 1
1.30(1.05–1.61)
KL 2
1.61(1.32–1.96)
KL 3
2.31(1.82–2.92)
KL 4
4.18(2.69–6.48)
Observational data: associations, not effects.
Further findings
Incident frequent knee symptoms · 48 months
- Results similar to 12 months
Original publication
Do Not Throw Out the Radiographs! Radiographic Disease Severity as a Prognostic Biomarker for the Onset of Frequent Knee Pain. J Rheumatol. Published 15 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →