Tribological impact of synovial fluid alterations in osteoarthritis: Correlation analyses between cartilage friction and synovial fluid properties
Authors' conclusion
The impact of SF alterations on AC friction depends on the tissue's degeneration severity.
Study context
- Population
- Patients undergoing knee replacement surgery; cartilage samples lubricated with patient-specific synovial fluid
- Participants
- 12 patients
- Comparison
- Mild vs Advanced
- Outcome
- Correlations between cartilage friction and synovial fluid viscosity and biochemical composition
Methodological detailsex vivo friction tests under simulated gait conditions, Spearman correlation analyses
- Ex vivo friction tests under simulated gait conditions
- Spearman correlation analyses
Main finding
As reported in the abstract
Correlations of cartilage friction with synovial fluid properties
- Mild
- Spearman ρ, µendStance vs proteoglycan 4 concentration −0.9 (95% CI −1.0 to −0.8); P < 0.01
- Mild
- Spearman ρ, µendSwing vs proteoglycan 4 concentration −0.7 (95% CI −0.9 to −0.3); P = 0.01
- Advanced · reported as significant positive correlation
- Spearman ρ, µendSwing vs viscosity η0.01(25 °C) −0.7 (95% CI −0.9 to −0.2); P = 0.01
- Advanced · reported as significant positive correlation
- Spearman ρ, µendSwing vs viscosity η1000(25 °C) −0.8 (95% CI −0.9 to −0.4); P = < 0.01
Original publication
Tribological impact of synovial fluid alterations in osteoarthritis: Correlation analyses between cartilage friction and synovial fluid properties. Osteoarthritis Cartilage. Published 7 November 2025. doi:10.
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