Usefulness of 3D joint space width on weight-bearing CT in comparison with 2D joint space width on radiographs for predicting 24-month worsening of knee osteoarthritis pain and function in the Multicenter Osteoarthritis Study (MOST) study
Performance · Prediction of MCIW of WOMAC pain (AUC)Result — go to the resultDifference 0.067 95% CI −0.040 to 0.175Authors' conclusion
3D-JSW on WBCT did not outperform 2D-JSWx on radiography for predicting knee pain and functional worsening.
Study context
- Population
- Multicenter Osteoarthritis Study (MOST) participants; mean age 63.2±8.9 years, body mass index (BMI) 28.2±4.8 kg/m²425 knees
- Participants
- 302 participants
- Comparison
- 3D-JSW on weight-bearing computed tomography (WBCT) vs 2D-JSWx on radiographs for predicting 24-month worsening of knee OA pain and function
- Outcome
- Minimal clinically important worsening (MCIW) of pain (WOMAC pain subscale) and function (20-m walk, sit-to-stand, WOMAC function subscale)
- Follow-up
- 24 months
Methodological detailsprognostic (predictive validity), logistic regression with generalized estimating equations (GEE), ROC AUC comparison, multicentre cohort (MOST)
- Prognostic (predictive validity)
- Logistic regression with GEE
- ROC AUC comparison
- Multicentre cohort (MOST)
Performance
Prediction of MCIW of WOMAC pain (AUC)
Difference
0.067
95% CI −0.040 to 0.175
By group
3D-JSW
0.578
AUC
2D-JSWx
0.511
AUC
3D-JSWvs 2D-JSWx
difference 0.067 (95% CI −0.040 to 0.175)
As reported in the abstract
Further findings
Minimal clinically important worsening (MCIW) in 20-m walk, difference in ROC AUC · 24 months
- Similar results (3D-JSW not superior to 2D-JSWx)
MCIW in sit-to-stand test, difference in ROC AUC · 24 months
- Similar results (3D-JSW not superior to 2D-JSWx)
MCIW in WOMAC function, difference in ROC AUC · 24 months
- Similar results (3D-JSW not superior to 2D-JSWx)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Usefulness of 3D joint space width on weight-bearing CT in comparison with 2D joint space width on radiographs for predicting 24-month worsening of knee osteoarthritis pain and function in the MOST study. Osteoarthritis Cartilage. Published 7 November 2025. doi:10.
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