Improved responsiveness to change in joint space width over 24-month follow-up: comparison of 3D JSW on weight-bearing CT vs 2D JSW on radiographs in the MOST study

Segal, NA; Nevitt, MC; Morales Aquino, M; McFadden, E; Ho, M; Duryea, J; Tolstykh, I; Cheng, H; He, J; Lynch, JA; Felson, DT; Anderson, DD

doi:10.1016/j.joca.2022.12.002

Improved responsiveness to change in joint space width over 24-month follow-up: comparison of 3D joint space width (JSW) on weight-bearing CT vs 2D JSW on radiographs in the MOST study

Osteoarthritis CartilagePublished 13 Dec 2022Measurement study (comparison of imaging modalities) within a prospective cohort

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Authors' conclusion

Subregional 3D JSW on WBCT is substantially more responsive to 24-month changes in tibiofemoral joint structure compared to radiographic measurements.

Study context

Population: Participants of the Multicenter Osteoarthritis Study (knee osteoarthritis (OA)), 144- and 168-month visits58.1% women
Participants: 265 participants

Exposure: 3D JSW on weight-bearing CT (WBCT) vs 2D JSW on radiographs
Outcome: Responsiveness to change: SRM for change in tibiofemoral JSW
Follow-up: 24 months

Methodological detailsancillary to the Multicenter Osteoarthritis Study (MOST), 24-month follow-up

Ancillary to the Multicenter Osteoarthritis Study (MOST)
24-month follow-up

Main finding

As reported in the abstract

Responsiveness (SRM) of JSWx change, medial tibiofemoral compartment

Group	Standardized response mean (SRM) range
3D JSWx	−0.18, −0.24
2D JSWx	−0.10, −0.16

Standardized response mean (SRM) range

3D JSWx−0.18, −0.24

2D JSWx−0.10, −0.16

Observational data: associations, not effects.

Further findings

Outcome	P value
Responsiveness (SRM) of subregional 3D JSW (CMF, CMT; maximal CLF/CLT) vs respective medial and lateral 2D JSWx · 24 months	P ≤ 0.002

Responsiveness (SRM) of subregional 3D JSW (CMF, CMT; maximal CLF/CLT) vs respective medial and lateral 2D JSWx — SRM range, subregional mean CMF and CMT 3D JSW: −0.06, −0.36
Responsiveness (SRM) of subregional 3D JSW (CMF, CMT; maximal CLF/CLT) vs respective medial and lateral 2D JSWx — SRM range, subregional maximal CMF and CMT 3D JSW: −1.14, −1.75

Responsiveness (SRM) of subregional 3D JSW (CMF, CMT; maximal CLF/CLT) vs respective medial and lateral 2D JSWx: statistically significantly greater responsiveness of 3D subregional JSW

Original publication

Improved responsiveness to change in joint space width over 24-month follow-up: comparison of 3D JSW on weight-bearing CT vs 2D JSW on radiographs in the MOST study. Osteoarthritis Cartilage. Published 13 December 2022. doi:10.1016/j.joca.2022.12.002

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