Association of ligament mechanical properties and articular surface topography with trapeziometacarpal kinematics across osteoarthritis stages
Authors' conclusion
This study suggests a relationship between ligament mechanics, articular surface topography, and joint kinematics. Clustering revealed links between VLC attenuation and kinematics in early OA.
Study context
- Population
- Cadaveric female trapeziometacarpal joints across osteoarthritis (OA) stages
- Participants
- 46 cadaveric female trapeziometacarpal (TMC) joints
- Comparison
- Cluster 1 vs Cluster 2 vs Cluster 3
Methodological detailscadaveric, principal component analysis and K-means clustering
- Cadaveric
- Principal component analysis and K-means clustering
Main finding
As reported in the abstract
- Three clusters emerged from principal component analysis (PCA) and K-means clustering
- Reduced metacarpal ulnar-radial global curvature in Cluster 3
- Range-of-motion (ROM) increased from Cluster 1-2 and decreased significantly from Cluster 2-3
- Volar ligament complex attenuation and minor dorsal radial ligament attenuation from Cluster 1-2, and from Cluster 2-3
Original publication
Association of ligament mechanical properties and articular surface topography with trapeziometacarpal kinematics across osteoarthritis stages. Osteoarthritis Cartilage. Published 4 November 2025. doi:10.
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