EULAR 2025 classification criteria for haemochromatosis arthropathy

Kiely, PD; Finzel, S; Farisogullari, B; Carroll, GJ; McCarthy, G; Stack, J; Parisi, S; Porto, G; Richette, P; Nagy, G; Weidl, M; Rosenthal, A; Guggenbuhl, P; Banaszkiewicz, KJ; Engelhardt, S; Shearman, JD; Mitchell, D; Barker, J; Brueton, V; Butzeck, B; Coathup, P; Don, H; Dowsett, J; Duncan, M; Dunleavy, T; Fish, I; Hoggarth, A; McKinnon, M; Minter, J; Osborne, T; Smith, M; Wright, C; Machado, PM

doi:10.1016/j.ard.2025.10.003

Osteoarthritis

EULAR 2025 classification criteria for haemochromatosis arthropathy

Ann Rheum DisPublished 4 Nov 2025Classification criteria development study

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Authors' conclusion

An international multicentre task force has developed the first classification criteria for HA from a unique derivation cohort using rigorous methodology.

Study context

Population: Patients recruited from routine care: Haemochromatosis arthropathy (HA) and disease mimics (primary generalised OA or CPPD)derivation cohort
Participants: 154 vs 120

Comparison: HA vs disease mimics
HAn = 154
Disease mimicsn = 120reference
Outcome: Classification criteria for HA

Methodological detailsEULAR standardised operating procedures, systematic literature review, consensus and Delphi process, multivariable logistic regression and ROC curve analysis, international multicentre task force

EULAR standardised operating procedures
Systematic literature review, consensus and Delphi process
Multivariable logistic regression and ROC curve analysis
International multicentre task force

Recommendations

As reported in the abstract

Point-based classification model (8 variables), score ≥5 out of 11

Specificity

93.3%

Sensitivity

71.4%

Reference

Authors: Kiely PD, Finzel S, Farisogullari B, Carroll GJ, McCarthy G, Stack J, et al.
All 33 authors
Kiely PD, Finzel S, Farisogullari B, Carroll GJ, McCarthy G, Stack J, Parisi S, Porto G, Richette P, Nagy G, Weidl M, Rosenthal A, Guggenbuhl P, Banaszkiewicz KJ, Engelhardt S, Shearman JD, Mitchell D, Barker J, Brueton V, Butzeck B, Coathup P, Don H, Dowsett J, Duncan M, Dunleavy T, Fish I, Hoggarth A, McKinnon M, Minter J, Osborne T, Smith M, Wright C, Machado PM
Journal: Annals of the Rheumatic Diseases
Published: 4 Nov 2025
DOI: 10.1016/j.ard.2025.10.003
PubMed: 41193334

Topic: Osteoarthritis

Group definitions

HA: patients with C282Y homozygous HFE gene mutation, joint pain, and iron loading

Key notes

8 variables: age of symptom onset, clinical and radiographic features at MCP, DIP and ankle joints, and surgery of hips or ankles

Original publication

EULAR 2025 classification criteria for haemochromatosis arthropathy. Ann Rheum Dis. Published 4 November 2025. doi:10.1016/j.ard.2025.10.003

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