Patient-Reported Outcomes in Calcium Pyrophosphate Deposition Disease Compared to Gout and Osteoarthritis
Authors' conclusion
Patients with CPPD may experience pain comparable to that in gout and OA and reported substantial unmet treatment needs.
Study context
- Population
- Patients with CPPD recruited from Brigham and Women's Hospital, 2018–2022 (mean age 71.9 years; 51% female)
- Participants
- 47 patients
- Exposure
- CPPD vs gout and osteoarthritis (OA)
- CPPDn = 47
Methodological detailssingle-centre, comparison with published gout and OA cohort studies
- Single-centre
- Comparison with published gout and OA cohort studies
Further findings
Mean
| Outcome | CPPD | Gout | OA | P value |
|---|---|---|---|---|
| Pain VAS during a flareCPPD vs Gout · similar | 6.8 (SD 1.9) | 6.7 (SD 2.6) | — not stated in the abstract | P = 0.78 |
| RAPID-3 scoresCPPD vs Gout · lower in CPPD | 8.1 (SD 5.6) | 12.1 (SD 6.2) | 6.8 (SD 6.1) | P < 0.01 |
| RAPID-3 scoresCPPD vs OA · similar | P = 0.30 |
— not stated in the abstract
- Unmet treatment need · CPPD vs Gout · significantly greater in CPPD
- P = 0.04
WOMAC stiffness and function
- Significantly worse WOMAC stiffness in CPPD than mild OA
- Significantly better WOMAC function in CPPD than severe OA
CPPD manifestations
- ≥1 episode of acute CPP crystal arthritis
- 68%
- Chronic CPP inflammatory arthritis
- 40%
- OA with CPPD
- 62%
Original publication
Patient-Reported Outcomes in Calcium Pyrophosphate Deposition Disease Compared to Gout and Osteoarthritis. J Rheumatol. Published 15 April 2023. doi:10.
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