Longitudinal patterns of C-reactive protein values in calcium pyrophosphate deposition disease
Authors' conclusion
We identified distinct patterns of CRP according to CPPD clinical phenotype. CRP was higher over time in patients with acute CPP crystal arthritis compared with chronic CPP inflammatory arthritis only.
Study context
- Population
- Participants in a single-centre CPPD registry with ≥1 C-reactive protein (CRP) value from CPPD diagnosis to March 2024 (mean ± SD age 68.2 ± 8.8 years; 63% female)264 CRP values
- Participants
- 54 participants
- Exposure
- CRP by inflammatory CPPD phenotype: acute CPP vs chronic CPP vs both acute & chronic CPP
- Outcome
- Log-transformed CRP (mg/L) by inflammatory CPPD phenotype, longitudinally
Methodological detailssingle-centre CPPD registry, generalized estimating equation (GEE) linear regression, mixed-effects model adjusted for age and sex
- Single-centre CPPD registry
- GEE linear regression
- Mixed-effects model adjusted for age and sex
Main finding
As reported in the abstract
Log-transformed CRP, GEE model
- Longitudinal CRP values fluctuated most widely in the acute CPP group
- Acute & chronic CPP vs Chronic CPP: P = 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| CRP over time, mixed-effects model adjusted for age and sexAcute & chronic CPP vs Chronic CPP · non-significantly higher | P = 0.15 |
| CRP over time, mixed-effects model adjusted for age and sexAcute CPP vs Chronic CPP · non-significantly higher | P = 0.12 |
- CRP over time, mixed-effects model adjusted for age and sex: median (IQR) follow-up 4.7 (2.7-7.9) years
Original publication
Longitudinal patterns of C-reactive protein values in calcium pyrophosphate deposition disease. Scand J Rheumatol. Published 22 May 2026. doi:10.
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