Features Associated With Different Inflammatory Phenotypes of Calcium Pyrophosphate Deposition Disease: A Study Using Data From the International American College of Rheumatology/EULAR Calcium Pyrophosphate Deposition Classification Criteria Cohort
Authors' conclusion
CPPD disease encompasses acute and chronic inflammatory phenotypes, each with specific clinical and imaging features that need to be considered in the diagnostic workup.
Study context
- Population
- People meeting the 2023 ACR/EULAR CPPD classification criteria in an international cohort (25 sites, 7 countries); 56% female; mean age 74.0 (SD 11.9) years56% female
- Participants
- 618 people
- Exposure
- Features associated with each inflammatory phenotype of CPPD disease
- Recurrent acute arthritisn = 332
- Persistent inflammatory arthritisn = 158
- Crowned dens syndrome (CDS)n = 45
- Outcome
- Disease, demographic and imaging features associated with each inflammatory phenotype of CPPD disease
Methodological detailsthree cross-sectional studies, international cohort (25 sites in 7 countries), multivariable logistic regression
- Three cross-sectional studies
- International cohort (25 sites in 7 countries)
- Multivariable logistic regression
Main finding
As reported in the abstract
Features associated with inflammatory phenotypes (aOR)
- Recurrent acute CPP crystal arthritis: longer disease duration, aOR
- 2.88 (2.00-4.14) (95% CI)
- Chronic CPP crystal inflammatory arthritis: acute wrist arthritis, aOR
- 2.92 (1.81-4.73) (95% CI)
- Chronic CPP crystal inflammatory arthritis: metacarpophalangeal joint OA, aOR
- 1.87 (1.17-2.97) (95% CI)
- Chronic CPP crystal inflammatory arthritis: Scapho-trapezo-trapezoid (STT) joint OA, aOR
- 1.83 (1.15-2.91) (95% CI)
- Chronic CPP crystal inflammatory arthritis: metabolic or familial risk for CPPD (negative association), aOR
- 0.60 (0.37-0.96) (95% CI)
- CDS: male sex, aOR
- 2.35 (1.21-4.59) (95% CI)
- CDS: STT joint OA, aOR
- 2.71 (1.22-6.05) (95% CI)
- CDS: more joints affected with chondrocalcinosis, aOR
- 1.46 (1.15-1.85) (95% CI)
Observational data: associations, not effects.
Further findings
Phenotype frequencies
- Phenotype frequencies — Experienced acute CPP crystal arthritis
- 602 (97.4%)
Original publication
Features Associated With Different Inflammatory Phenotypes of Calcium Pyrophosphate Deposition Disease: A Study Using Data From the International American College of Rheumatology/EULAR Calcium Pyrophosphate Deposition Classification Criteria Cohort. Arthritis Rheumatol. Published 22 August 2024. doi:10.
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