Intestinal uric acid excretion contributes to serum uric acid decrease during acute gout attack
Authors' conclusion
Increased intestinal urate excretion resulted in spontaneous SUA downregulation during acute gout attacks. Inflammation-induced PI3K/Akt activation and ABCG2 expression in epithelial cells might contribute to the upregulation of intestinal uric acid excretion.
Study context
- Population
- Patients with gout; Caco2 cells; Monosodium urate (MSU)-induced gout model of wild-type and ABCG2-/- mice
- Outcome
- Spontaneous regulation of sUA during a gout attack and its possible causes
- Follow-up
- Acute gout attack
Methodological detailspatients with gout, Caco2 cell transwell culture, MSU-induced gout model in wild-type and ABCG2-/- mice
- Patients with gout
- Caco2 cell transwell culture
- MSU-induced gout model in wild-type and ABCG2-/- mice
Main finding
As reported in the abstract
acute gout attacks
- sUA decreased during acute gout attacks in both gout patients and MSU-induced gouty mice
- Increased serum CRP and IL-1β levels correlated with the sUA decrease
- Intestinal uric acid excretion and ABCG2 expression upregulated in mice during acute gout attacks
- In ABCG2-/- mice, intestinal uric acid excretion significantly decreased during gout attacks
- In vitro (transwell), ABCG2 and upstream PI3K/Akt pathway significantly upregulated in intestinal epithelial cells
- ABCG2 expression and intestinal uric acid transport inhibited when PI3K/Akt blocked by PI3K inhibitor LY294002
Original publication
Intestinal uric acid excretion contributes to serum uric acid decrease during acute gout attack. Rheumatology (Oxford). Published 12 April 2023. doi:10.
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