Predictors of disease activity in gout: a 12-month analysis of the ATTACk (Achieving improvement in the management of crystal-induced arthritis) multicentre cohort study
Authors' conclusion
The baseline presence of tophi may predict high disease-activity at T12, thus worsening GAS and patients' pain perception.
Study context
- Population
- Consecutive patients with clinical diagnosis of gout referred to Rheumatology Units for suspected acute crystal-induced arthritis (mean age 63±13 years, 88% men)113 (56%) followed up at T12
- Participants
- 201 patients
- Exposure
- Presence vs absence of tophi at baseline
- Outcome
- Predictors of gout disease activity: PASS (VAS 0–100) and GAS
- Follow-up
- 12 months
Methodological detailsmulticentre, consecutive patients, multivariate linear regression
- Multicentre
- Consecutive patients
- Multivariate linear regression
Main finding
As reported in the abstract
Association of tophi with disease activity at T12
Regression coefficient (Patient Acceptable Symptom State (PASS) at T12)
−15.3
95% CI −25.5 to −5.2P = 0.003
Tophi
Regression coefficient (Gout Activity Score (GAS) at T12)
+4.0
95% CI 0.6,7.4P = 0.02
Tophi
Observational data: associations, not effects.
Further findings
Mean PASS (visual analogue scale (VAS) 0–100) and GAS, whole cohort · T0 and T12
- Mean PASS at T0
- 38±27
- Mean PASS at T12
- 74±23
- GAS at T12
- 10±8
Original publication
Predictors of disease activity in gout: a 12-month analysis of the ATTACk (Achieving improvement in the management of crystal-induced arthritis) multicentre cohort study. Clin Exp Rheumatol. Published 24 February 2022. doi:10.
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