Addition of allopurinol to traditional Vietnamese medicine shows major improvement of 100 gout patients in a single center one-year prospective study
Authors' conclusion
This shift in practice resulted in dramatic gout improvement.
Study context
- Population
- Vietnamese, ULD-free, crystal-proven gout patients with GFR>60mL/min; median age 47 years, disease duration 8 years; 91 with clinical tophi, 70 with foot gouty erosions84 seen at 6 mo, 68 at 12 mo
- Participants
- 100 participants
- Exposure
- Allopurinol (treat-to-target) added to traditional herbal medicine; patients reaching serum urate (SU) targets at 3 months vs those who did not
Methodological detailssingle-centre, open, one-year
- Single-centre
- Open
- One-year
Main finding
As reported in the abstract
- Significant improvement of flare rates at M6 and M12, not associated with SU targets
- Significant improvement of GIS and function at M12, not associated with SU targets
- Tophi (photograph and ultrasound (US)) and double contour (DC) sign significantly decreased from M6, in association with achieving <300μmol/L SU target
- Foot erosion scores significantly decreased, no association with SU targets
Observational data: associations, not effects.
Further findings
Allopurinol dosage
- Progressively increased to median 600mg/d
Safety
Mild skin rash to allopurinol
- Patients with mild skin rash
- 7
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Addition of allopurinol to traditional Vietnamese medicine shows major improvement of 100 gout patients in a single center one-year prospective study. Joint Bone Spine. Published 15 March 2025. doi:10.
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