Remission in gout is possible: 5-year follow-up in the NOR-Gout study
Authors' conclusion
Remission in gout after urate lowering therapy was seldom after 1 but high after 5 years and was highest for the simplified definition. Remission definitions showed concurrent validity for quality of life and structural changes.
Study context
- Population
- Patients with crystal proven gout, increased serum urate and a flare, in an intensive 1-year treat-to-target intervention (mean age 56.4 years, 95.3 % males)
- Participants
- 211 patients
- Exposure
- Preliminary vs modified preliminary vs simplified gout remission definitions
- Outcome
- Frequency of remission by each remission definition
- Follow-up
- 1, 2 and 5 years
Methodological detailstreat-to-target, 5-year follow-up, linear mixed models
- Treat-to-target
- 5-year follow-up
- Linear mixed models
Main finding
As reported in the abstract
Frequency of remission (1, 2 and 5 years)
- Preliminary: year 1
- 4.6 %
- Preliminary: year 2
- 22.1 %
- Preliminary: year 5
- 42.8 %
- Modified preliminary: year 1
- 5.1 %
- Modified preliminary: year 2
- 28.4 %
- Modified preliminary: year 5
- 44.1. %
- Simplified: year 1
- 7.7 %
- Simplified: year 2
- 45.4 %
- Simplified: year 5
- 58.6 %
- Increase over time, all definitions
- p < 0.001
Observational data: associations, not effects.
Further findings
Discrimination for SF-36 MCS, PCS or DECT structural damage
- All three definitions discriminated for SF-36 MCS, PCS or DECT
Original publication
Remission in gout is possible: 5-year follow-up in the NOR-Gout study. Semin Arthritis Rheum. Published 27 February 2025. doi:10.
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