Associations of the ALDH2 rs671 polymorphism and alcohol intake with early-onset gout in a Chinese male cohort
Authors' conclusion
The ALDH2 rs671 GG genotype was significantly associated with a lower risk of early-onset gout, while individuals with the AA or AG genotype who consumed alcohol were more susceptible.
Study context
- Population
- Chinese men with goutChinese men with gout
- Participants
- 1,201 men
- Exposure
- Early-onset gout vs later-onset gout
- Early-onset goutn = 433
- Outcome
- Early-onset gout (association of single nucleotide polymorphisms (SNPs) and clinical factors)
Methodological detailsgenetic association, logistic regression
- Genetic association
- Logistic regression
Main finding
As reported in the abstract
Early-onset gout
Early-onset gout
36.1%
433
Observational data: associations, not effects.
Further findings
Serum urate (SU) levels and gout flares, early- vs later-onset
- Early-onset gout had higher SU levels and were more likely to experience gout flares than later-onset gout
Gout flares in early-onset gout by alcohol intake
- Alcohol intake significantly increased the likelihood of gout flares in early-onset gout
Original publication
Associations of the ALDH2 rs671 polymorphism and alcohol intake with early-onset gout in a Chinese male cohort. Joint Bone Spine. Published 25 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →