Consumption of Total and Specific Alcoholic Beverages and Long-Term Risk of Gout Among Men and Women
Authors' conclusion
In this cohort study, higher consumption of several specific alcoholic beverages was associated with a higher risk of gout among both sexes.
Study context
- Population
- UK Biobank participants aged 37 to 73 years free of gout at baseline (2006–2010), followed through December 31, 2021UK Biobank
- Participants
- 401,128 participants
- Exposure
- Alcohol consumption vs never drinking, by sex
- Menn = 179,828
- Womenn = 221,300
- Outcome
- Incident gout, identified using hospital records
Methodological detailsmultivariable Cox proportional hazards regression, sex-specific analyses, consideration of reverse causation bias, Followed up through December 31, 2021; analysed August 2023 to June 2024
- Multivariable Cox proportional hazards regression
- Sex-specific analyses
- Consideration of reverse causation bias
- Followed up through December 31, 2021; analysed August 2023 to June 2024
Main finding
As reported in the abstract
Incident gout, current vs never drinkers
Hazard ratio (95% CI)
Current drinkers (men)vs Never drinkers (men)
1.69(1.30–2.18)
Current drinkers (women)vs Never drinkers (women)
0.83(0.67–1.03)
Observational data: associations, not effects.
Further findings
Beer or cider consumption
| Outcome | Men | Women |
|---|---|---|
| Incident gout with higher total alcohol consumption among current drinkers | ||
| HR | 2.05 (95% CI, 1.84-2.30) | 1.34 (95% CI, 1.12-1.61) |
| Incident gout per 1 pint per day of beer or cider | ||
| HR | 1.60 (95% CI, 1.53-1.67) | 1.62 (95% CI, 1.02-2.57) |
Incident gout per 1 pint per day of beer or cider
- Champagne or white wine, beer or cider, and spirits each associated with higher gout risk in both sexes
Light to moderate consumption of specific beverages
- Some inverse associations with gout eliminated after adjusting for other beverages and excluding those at risk of reverse causation
Original publication
Consumption of Total and Specific Alcoholic Beverages and Long-Term Risk of Gout Among Men and Women. JAMA Netw Open. Published 1 August 2024. doi:10.
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