Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity
Authors' conclusion
In this large study of European participants, novel interactions with alcohol consumption were identified at ADH1B and MLXIPL for association with serum urate level and at ADH1B for association with hyperuricaemia and gout.
Study context
- Population
- European participants of the UK Biobank
- Participants
- 458,405 European participants
- Comparison
- SNP–alcohol consumption interactions for serum urate, hyperuricaemia and gout
- Outcome
- SNP–alcohol consumption interactions for serum urate level, hyperuricaemia and gout
Methodological detailsUK Biobank, gene–environment interaction analysis, multivariable-adjusted linear and logistic regression, genotype-stratified association analyses
- UK Biobank
- Gene–environment interaction analysis
- Multivariable-adjusted linear and logistic regression
- Genotype-stratified association analyses
Main finding
As reported in the abstract
SNP–alcohol consumption interactions
Interaction with alcohol for serum urate: rs1229984 (ADH1B), P
3.0 × 10-44
Interaction with alcohol for serum urate: rs6460047 (MLXIPL), P
1.4 × 10-4
ADH1B interaction with alcohol for hyperuricaemia, P
7.9 × 10-13
ADH1B interaction with alcohol for gout, P
8.2 × 10-9
Further findings
Interaction by beverage type and sex (ADH1B)
- Beer intake had the most significant interaction with ADH1B for serum urate and gout among men; wine intake among women
Genotype-stratified analyses
- ADH1B and MLXIPL associated with serum urate, and ADH1B with hyperuricaemia and gout, among alcohol consumers but not non-consumers
Original publication
Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity. Arthritis Res Ther. Published 8 February 2024. doi:10.
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