Fractures in Patients With Acute Calcium Pyrophosphate Crystal Arthritis Versus Matched Comparators in a Large Cohort Study
Main finding · First fracture (humerus, wrist, hip, pelvis)Result — go to the resultAdjusted hazard ratio 1.8 95% CI 1.3–2.3Authors' conclusion
In this first published study of fractures and CPPD, fracture risk was nearly doubled in patients with acute CPP crystal arthritis.
Study context
- Population
- Patients with acute CPP crystal arthritis and matched comparators, single academic health system, 1991–2023 (mean age 73 years); patients with prior fracture excludedmatched cohort
- Participants
- 1,148 vs 3,730
- Exposure
- Acute CPP crystal arthritis vs matched comparators
- Acute CPP crystal arthritisn = 1,148
- Comparatorsn = 3,730reference
- Outcome
- First fracture at the humerus, wrist, hip, or pelvis
Methodological detailslongitudinal, matched, single large academic health system, electronic health record data
- Longitudinal
- Matched
- Single large academic health system
- Electronic health record data
Main finding
First fracture (humerus, wrist, hip, pelvis)
Adjusted hazard ratio
1.8
95% CI 1.3–2.3
By group
Acute CPP crystal arthritisvs Comparators
aHR 1.8 (95% CI 1.3–2.3)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Sensitivity analyses (excluding GC, osteoporosis treatment or RA; adjusting for CKD)
- Results similar in sensitivity analyses
Original publication
Fractures in Patients With Acute Calcium Pyrophosphate Crystal Arthritis Versus Matched Comparators in a Large Cohort Study. Arthritis Rheumatol. Published 8 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →