The Significance of Intracellular Versus Extracellular Calcium Pyrophosphate Crystals in Diagnosing Calcium Pyrophosphate Crystal Arthritis
Authors' conclusion
The presence of intracellular CPP crystals is more strongly associated with acute/chronic CPP crystal arthritis than with extracellular CPP crystals alone.
Study context
- Population
- Patients with synovial fluid samples positive for CPP crystals, Waikato District Health Board
- Participants
- 134 patients
- Exposure
- Intracellular vs extracellular CPP crystals in synovial fluid
- Intracellularn = 108
- Extracellularn = 26reference
- Outcome
- Proportion diagnosed with acute/chronic CPP crystal arthritis (synovial CPP crystals, objective joint inflammation, no alternative diagnosis)
Main finding
As reported in the abstract
Acute/chronic CPP crystal arthritis diagnosed
P < 0.001
Observational data: associations, not effects.
Further findings
Acute/chronic CPP crystal arthritis diagnosed, after exclusion of septic arthritis cases
P < 0.001
Original publication
The Significance of Intracellular Versus Extracellular Calcium Pyrophosphate Crystals in Diagnosing Calcium Pyrophosphate Crystal Arthritis. J Rheumatol. Published 1 October 2024. doi:10.
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