Gout & crystal arthritis

Acute calcium pyrophosphate crystal arthritis is associated with an increased rate of hip and knee joint surgery

Rheumatology (Oxford)Published Retrospective cohort study

Main finding · Hip and knee joint arthroplasty rateResult — go to the resultStandardized surgical rate ratio 2.54 95% CI 1.39–4.27

Authors' conclusion

Our study identified a considerable increase in the rate of hip and knee joint arthroplasties in patients with episodes of acute CPP crystal arthritis.

Study context

Population
Patients with acute CPP crystal arthritis, Waikato District Health Board, New Zealand (63 male; median age 77 years)63 male
Participants
99 patients
Exposure
Acute CPP crystal arthritis cohort vs age-ethnicity-matched New Zealand population
  • Acute CPP crystal arthritisn = 99
Outcome
Rate of hip and knee joint arthroplasties (estimate of structural joint damage accrual), New Zealand Orthopaedic Association's Joint Registry
Methodological detailscomparison with age-ethnicity-matched New Zealand population
  • Comparison with age-ethnicity-matched New Zealand population

Main finding

Hip and knee joint arthroplasty rate

Standardized surgical rate ratio

2.54

95% CI 1.39–4.27

Acute CPP crystal arthritisvs New Zealand population
standardized surgical rate ratio 2.54 (95% CI 1.39–4.27)

As reported in the abstract

Observational data: associations, not effects.

Further findings

Obesity (BMI) in the cohort vs NZ population

Obesity rate
36%
Median BMI 28.4 kg/m² (IQR 25.8-32.2), comparable to the NZ population

Original publication

Acute calcium pyrophosphate crystal arthritis is associated with an increased rate of hip and knee joint surgery. Rheumatology (Oxford). Published 20 June 2023. doi:10.1093/rheumatology/kead305

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