Risk of Venous Thromboembolism With Gout Flares
Main finding · VTE incidenceResult — go to the resultAdjusted incidence rate ratio 1.83 95% CI 1.30–2.59Authors' conclusion
Among patients with gout, there was a transient increase in the rate of VTE within 30 days after primary-care consultation or hospitalization for gout flare.
Study context
- Population
- Adults (≥18 years) with incident gout and venous thromboembolism (VTE), without prior VTE or anticoagulant prescription; UK Clinical Practice Research Datalink
- Participants
- 314 adults
- Exposure
- Exposed period vs baseline period
- Outcome
- VTE incidence (adjusted IRR, exposed vs baseline period)
- Follow-up
- 90 days after gout flare
Methodological detailsadjusted for season and age, electronic primary-care records linked to hospitalization and mortality registers
- Adjusted for season and age
- Electronic primary-care records linked to hospitalization and mortality registers
Main finding
VTE incidence
Adjusted incidence rate ratio
1.83
95% CI 1.30–2.59
Exposed periodvs Baseline period
adjusted IRR 1.83 (95% CI 1.30–2.59)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted IRR (95% CI) | |
|---|---|---|
| VTE, first 30 days after gout flareFirst 30 daysvs Baseline | 2.31 (1.39–3.82) | |
| VTE, days 31-60Days 31-60vs Baseline | 1.49 (0.79–2.81) | |
| VTE, days 61-90Days 61-90vs Baseline | 1.67 (0.91–3.06) | |
| 0.20.5125Adjusted incidence rate ratio (log scale) |
Sensitivity analyses
- Results were consistent across sensitivity analyses
Original publication
Risk of Venous Thromboembolism With Gout Flares. Arthritis Rheumatol. Published 15 June 2023. doi:10.
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