A Mendelian randomization study of serum uric acid with the risk of venous thromboembolism
Authors' conclusion
Our MR analysis provided no compelling evidence for a causal relationship of serum uric acid with the risk of VTE.
Study context
- Population
- European individuals; uric acid instruments from CKDGen consortium and UK biobank; Venous thromboembolism (VTE), deep venous thrombosis (DVT) and pulmonary embolism (PE) outcomes from FinnGen biobank
- Comparison
- Genetically instrumented serum uric acid levels and risk of VTE, DVT and PE
- Outcome
- Causal association of serum uric acid with VTE and its subtypes (DVT of the lower extremities, PE)
Methodological detailstwo-sample, inverse-variance weighted primary estimate, MR-Egger, weighted median and MR-PRESSO complementary methods, sensitivity analyses for pleiotropic bias
- Two-sample
- Inverse-variance weighted primary estimate
- MR-Egger, weighted median and MR-PRESSO complementary methods
- Sensitivity analyses for pleiotropic bias
Main finding
As reported in the abstract
VTE, DVT and PE
- Genetically instrumented serum uric acid levels had no causal effects on VTE, DVT and PE
Further findings
Two instrument sets and three complementary Mendelian randomization (MR) methods
- No significant association
Original publication
A Mendelian randomization study of serum uric acid with the risk of venous thromboembolism. Arthritis Res Ther. Published 19 July 2023. doi:10.
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