Prediagnostic Glycoprotein Acetyl Levels and Incident and Recurrent Flare Risk Accounting for Serum Urate Levels: A Population‐Based , Prospective Study and Mendelian Randomization Analysis
Main finding · Incident gout, GlycA extreme quintiles, urate-adjustedResult — go to the resultHazard ratio 1.52 95% CI 1.22–1.88Authors' conclusion
This prospective, population-based study implicates GlycA, a stable long-term biomarker reflecting neutrophil overactivity, in incident and recurrent gout flares (central manifestation from neutrophilic synovitis) beyond serum urate.
Study context
- Population
- UK Biobank participants without history of gout with NMR metabolomic profiling data (168 metabolites) from baseline blood samples, 2006–20101,303 incident gout cases
- Participants
- 105,615 participants
- Exposure
- Extreme quintiles of glycoprotein acetyl (glycoprotein acetyls (GlycA)) levels, adjusted for gout risk factors and serum urate
- Outcome
- Incident gout
Methodological detailspopulation-based, prediagnostic metabolome-wide analysis, 2-sample Mendelian randomization, Poisson regression
- Population-based
- Prediagnostic metabolome-wide analysis
- 2-sample Mendelian randomization
- Poisson regression
Main finding
As reported in the abstract
Incident gout, GlycA extreme quintiles, urate-adjusted
Hazard ratio
1.52
95% CI 1.22–1.88
GlycA
HR 1.52 (95% CI 1.22–1.88)
Observational data: associations, not effects.
Further findings
Incident gout, GlycA extreme quintiles, ≥8 hours of fasting
| HR (95% CI) | ||
|---|---|---|
| GlycABetween extreme quintiles | 4.01 (1.36–11.82) | |
| 0.050.21520Hazard ratio (log scale) |
Recurrent gout flares among incident gout cases, GlycA extreme quintiles
| RR (95% CI) | ||
|---|---|---|
| GlycABetween extreme quintiles | 1.90 (1.27–2.85) | |
| 0.20.5125Relative risk (log scale) |
| Outcome | HR per SD (95% CI) | |
|---|---|---|
| Incident gout per SD change in GlycAGlycA · overall | 1.10 (1.04–1.17) | |
| Incident gout per SD change in GlycAGlycA · ≥8 hours of fasting | 1.54 (1.21–1.96) | |
| 0.512Hazard ratio per SD (log scale) |
Recurrent gout flares among incident gout cases, GlycA extreme quintiles
- Larger associations with fasting
Mendelian randomization
- Corroborated a potential causal role for GlycA on gout risk
Original publication
Prediagnostic Glycoprotein Acetyl Levels and Incident and Recurrent Flare Risk Accounting for Serum Urate Levels: A Population‐Based , Prospective Study and Mendelian Randomization Analysis. Arthritis Rheumatol. Published 12 July 2023. doi:10.
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