Development and validation of an OMERACT ultrasound scoring system for the extent of calcium pyrophosphate crystal deposition at the joint level and patient level
Authors' conclusion
This OMERACT ultrasound scoring system for CPPD was reliable on both static images and patients.
Study context
- Population
- Members of the OMERACT US working group-CPPD subgroup; static images and patients with CPPDpatients recruited
- Participants
- 8 members
- Outcome
- Intra-reader and inter-reader reliability of the new US scoring system for CPPD extent (weighted Light's κ)
Methodological detailsDelphi survey, web-based and patient-based reliability exercise, OMERACT methodology, Score: grade 0 (no findings consistent with CPPD), grade 1 (≤3 single spots or 1 small deposit), grade 2 (>3 single spots or >1 small deposit or ≥1 larger deposit occupying ≤50% of the structure), grade 3 (deposits occupying >50% of the structure) in the reference image, Applied to the knee (menisci and hyaline cartilage) and the triangular fibrocartilage complex of the wrist
- Delphi survey
- Web-based and patient-based reliability exercise
- OMERACT methodology
- Score: grade 0 (no findings consistent with CPPD), grade 1 (≤3 single spots or 1 small deposit), grade 2 (>3 single spots or >1 small deposit or ≥1 larger deposit occupying ≤50% of the structure), grade 3 (deposits occupying >50% of the structure) in the reference image
- Applied to the knee (menisci and hyaline cartilage) and the triangular fibrocartilage complex of the wrist
Main finding
As reported in the abstract
Reliability of the four-grade semiquantitative CPPD US score
Intra-reader reliability, static images
κ 0.90
95% CI 0.79–1.00; almost perfect
Inter-reader reliability, static images (κ, 0.79-0.88; almost perfect)
0.84
Intra-reader reliability, patients
κ 0.72
95% CI 0.47 to 0.96; substantial
Inter-reader reliability, patients (κ, 0.61 to 0.71; substantial)
0.66
Observational data: associations, not effects.
Original publication
Development and validation of an OMERACT ultrasound scoring system for the extent of calcium pyrophosphate crystal deposition at the joint level and patient level. Lancet Rheumatol. Published 5 July 2023. doi:10.
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