Lowering Serum Urate With Urate‐Lowering Therapy to Target and Incident Fracture Among People With Gout
Authors' conclusion
In this population-based study, lowering the SU level with ULT to the guideline-based target level was associated with a lower risk of incident fracture in people with gout.
Study context
- Population
- Individuals with gout aged 40 years or older initiating urate-lowering therapy (ULT), UK primary care database (The Health Improvement Network)
- Participants
- 28,554 individuals
- Exposure
- Lowering serum urate (SU) with ULT to target vs not achieving target SU level
- Outcome
- Hip fracture
- Follow-up
- 5 years
Methodological detailscloning, censoring, and weighting approach, UK primary care database (The Health Improvement Network)
- Cloning, censoring, and weighting approach
- UK primary care database (The Health Improvement Network)
Main finding
As reported in the abstract
Hip fracture risk
Each group vs not achieving the target SU levelRisk difference (95% CI)
Achieving the target SU level
−0.3%(−0.5% to −0.1%)
Each group vs not achieving the target SU levelHazard ratio (95% CI)
Achieving the target SU level
0.66(0.46–0.93)
Observational data: associations, not effects.
Further findings
Composite fracture, major osteoporotic fracture, vertebral fracture and nonvertebral fracture
- Similar results were observed
Original publication
Lowering Serum Urate With Urate‐Lowering Therapy to Target and Incident Fracture Among People With Gout. Arthritis Rheumatol. Published 25 May 2023. doi:10.
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