Serum Urate and Recurrent Gout
Main finding · Rate of recurrent acute gout flares per 1000 person-years, by baseline serum urateResult — go to the resultRate ratio 1.61 CI 1.54–1.68Authors' conclusion
In this retrospective study of patients with a history of gout, serum urate levels at baseline were associated with the risk of subsequent gout flares and rates of hospitalization for recurrent gout.
Study context
- Population
- Patients with a history of gout identified in the UK 2006–2010, followed via Primary Care Linked Data to 2017 and Hospital Episode Statistics to 2020 (mean age 60 years; 86% men)1,773 gout flares
- Participants
- 3,613 patients
- Exposure
- Baseline serum urate categories
- Outcome
- Rate of recurrent acute gout (hospitalization, outpatient and prescription/procedure records); adjusted rate ratios by negative binomial regression
Methodological detailsnegative binomial regression
- Negative binomial regression
Main finding
As reported in the abstract
Rate of recurrent acute gout flares per 1000 person-years, by baseline serum urate · over 10 years
Rate ratio
1.61
CI 1.54–1.68
By group
Per mg/dL
rate ratio 1.61 (CI 1.54–1.68)
Per mg/dL, as printed
Observational data: associations, not effects.
Further findings
| Outcome | Values | Adjusted rate ratio (CI) | |
|---|---|---|---|
| Hospitalization for gout per 1000 person-years; rate ratio adjusted for age, sex, race | <6 mg/dL 0.18 per 1000 person-years · adjusted rate ratio 1.0 · 6.0–6.9 mg/dL 0.97 per 1000 person-years · adjusted rate ratio 4.70 · 7.0–7.9 mg/dL 1.8 per 1000 person-years · adjusted rate ratio 8.94 · 8.0–8.9 mg/dL 2.2 per 1000 person-years · adjusted rate ratio 10.37 · 9.0–9.9 mg/dL 6.7 per 1000 person-years · adjusted rate ratio 33.92 · ≥10 mg/dL 9.7 per 1000 person-years · adjusted rate ratio 45.29 | 1.87 (1.57–2.23) | |
| 0.512Adjusted rate ratio (log scale) |
Original publication
Serum Urate and Recurrent Gout. JAMA. Published 6 February 2024. doi:10.
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