Safety and efficacy of colchicine in crystal-induced arthritis flare in 54 patients with severe chronic kidney disease
Authors' conclusion
The use of colchicine, at reduced doses, was mostly effective to treat crystal-induced arthritis flare in 54 patients with severe CKD and was well tolerated, without any serious adverse events.
Study context
- Population
- Hospitalised patients with severe chronic kidney disease (CKD) (eGFR <30 mL/min) and crystal-induced arthritis flare (gout or CPPD), September 2020 to September 202162 colchicine prescriptions
- Participants
- 54 patients
- Outcome
- Tolerance and efficacy of colchicine
- Follow-up
- D1 to D11
Methodological detailssingle-group, hospitalised patients, Data prospectively collected from D1 to D11
- Single-group
- Hospitalised patients
- Data prospectively collected from D1 to D11
Main finding
As reported in the abstract
Colchicine well tolerated
Colchicine
77%
47/61 of 54
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Colchicine completely effective (judged by medical team)Per case | Colchicine 83% |
Safety
| Outcome | Values |
|---|---|
| Tolerance of colchicine (well tolerated) · D1 to D11Cases (colchicine prescriptions) | Colchicine 77% |
Serious adverse events
- No serious adverse event was reported
Original publication
Safety and efficacy of colchicine in crystal-induced arthritis flare in 54 patients with severe chronic kidney disease. RMD Open. Published 31 January 2024. doi:10.
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