Weight Reduction and Target Serum Urate Level: A Longitudinal Study of Annual Medical Examination
Authors' conclusion
Small weight reductions were associated with only small SU changes. Some participants with hyperuricemia can achieve the target SU level with moderate to large weight reductions.
Study context
- Population
- Annual medical examination participants, October 2012 to October 2022 (median age 46 years, 51.3% female, 19.4% with overweight, median serum urate (SU) 5.3 mg/dL, 5.6% with history of gout and/or hyperuricaemia)
- Participants
- 58,630 participants336,814 visits
- Exposure
- Weight reduction categories vs minimal weight change
- Outcome
- SU changes between two consecutive visits; achieving SU <6 mg/dL in participants with hyperuricaemia (SU ≥7 mg/dL at previous visit)
Methodological detailsannual medical examination data, linear general estimating equations, modified Poisson regression, adjusted for relevant covariates, Median follow-up 5.3 years
- Annual medical examination data
- Linear general estimating equations
- Modified Poisson regression
- Adjusted for relevant covariates
- Median follow-up 5.3 years
Main finding
As reported in the abstract
Adjusted mean SU change with weight reduction vs minimal change
Each group vs minimalMean SU change, mg/dL (95% CI)
Small
−0.10(−0.10 to −0.09)
Moderate
−0.34(−0.36 to −0.32)
Large
−0.64(−0.70 to −0.58)
Observational data: associations, not effects.
Further findings
| Outcome | Small | Moderate | Large | Adjusted RR (95% CI) | |
|---|---|---|---|---|---|
| Achieving SU <6 mg/dL in participants with hyperuricaemiaSmallvs MinimalCo-primary outcome | 1.25 (1.15–1.37) | ||||
| NNT | 61.1 | 8.5 | 3.6 | ||
| Achieving SU <6 mg/dL in participants with hyperuricaemiaModeratevs MinimalCo-primary outcome | 2.82 (2.43–3.27) | ||||
| Achieving SU <6 mg/dL in participants with hyperuricaemiaLargevs MinimalCo-primary outcome | 5.27 (4.15–6.70) | ||||
| 0.10.31310Adjusted relative risk (log scale) |
Original publication
Weight Reduction and Target Serum Urate Level: A Longitudinal Study of Annual Medical Examination. Arthritis Rheumatol. Published 31 October 2024. doi:10.
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